Antibody Research Hub

Exploring the frontier of AI-driven antibody design: de novo platforms, developability prediction, and therapeutic benchmarks.

Research & Analyses

Comprehensive analyses of de novo antibody design platforms and developability prediction.

New - Feb 2026

Does Developability Come For Free?

FLAb Dataset Analysis

Testing whether de novo antibody design models learn therapeutic-like developability without explicit training. Analysis of 160 FLAb datasets reveals training data bias as the explanation for "emergent" developability.

0.74
Immuno AUROC
d=-1.19
Effect Size
-0.27
ESM-2 Corr
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Benchmark Proposal

DADB-v1.0: A Therapeutic Decathlon

De Novo Antibody Design Benchmark

The first comprehensive benchmark measuring what actually matters for therapeutic antibodies: binding, structure, developability, and immunogenicity. A composite scoring system for the field.

40%
Binding Weight
25%
Structure
20%
Developability
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Platform Comparison

Antibodies from Thin Air

Five AI Platforms Rewriting Cancer Drug Discovery

A comprehensive comparison of JAM-2, Chai-2, Origin-1, RFAntibody, and Latent-X2. Covers hit rates, binding affinities, oncology targets, and the first immunogenicity data for AI-designed antibodies. Includes a primer on antibody biology for newcomers.

50%
Best Hit Rate
26.2 pM
Best Affinity
5
Platforms
First
Immuno Data
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