Open Menu
Meetings & Education
Meetings & Education
Research & Data
Practice & Patients
Career Development
News & Initiatives
Get Involved
In-bedroom renewed air as anti-inflammatory adjuvant therapy in cancer survivors: BREATHS trial.
Background:
Inflammation plays a pivotal role in both cancer progression and adverse cardiovascular (CV) effects of anticancer treatments. Cardio-oncology rehabilitation with inflammatory pathways-targeting therapies is emerging as a promising approach for cancer survivors at high risk of CV toxicity. In-home air filtration interventions effectively lower interleukin-6 levels in high-risk populations for CV and respiratory events and significantly impact C-reactive protein (CRP) levels in patients with atherosclerosis. Evidence indicates that CRP can serve as a reliable clinical indicator of residual inflammatory risk and cardiotoxicity after cancer therapy. Concurrent administration of purified air therapy along with conventional pharmacological agents—including statins, cyclooxygenase inhibitors, and beta-blockers—may potentiate the desired therapeutic effect, yet the underlying interactions are not fully understood. We investigate whether overnight in-bedroom air filtration effectively reduces inflammation and cardiac markers in survivors of adult-onset cancer at high risk of CV toxicity.
Methods:
This is a series of N-of-1 randomized, adaptive, blinded, and placebo-controlled trials conducted in the homes of adult survivors residing in densely populated urban areas of Valencia, Spain, with the poorest air quality levels, as evidenced by particulate matter concentrations exceeding the WHO and EU Directive limits. Inclusion criteria are age ≥ 18 years, prior history of breast, colorectal, prostate, lung, or hematologic cancer, exposure to cardiotoxic cancer therapy, and CRP level ≥ 3 mg/L. Participants will be randomly assigned to three treatment sets, each comprising a 14-day period of active therapy (portable air purifier at 275 m3/h) and a 14-day period of placebo (sham purification). In-bedroom air filtration treatment and placebo will be administered nightly for a minimum of 7 consecutive hours. The blinded sequence will last between 4 and 12 weeks per participant, depending on the clinical efficacy evidenced after each treatment set (CRP < 2 mg/L or CRP reductions ≥ 35%). Participants who fail to achieve the clinically meaningful change in the last treatment set will undergo an open-label phase: 14 days of no treatment and 14 days of active therapy administered nightly and daily (air purifier operating continuously at 275 m3/h). Participants will be asked to keep a daily in-bedroom time log. The primary endpoint is defined as the change in blood CRP levels after each cycle. Secondary outcomes include changes in D-dimer, serum amyloid A and glycated hemoglobin A1c concentrations, and blood pressure. Exploratory endpoints include the feasibility of at-home point-of-care testing to monitor residual inflammatory toxicity. Ten participants will be enrolled in the trial. No enrolled participants at the time of abstract submission. Clinical trial information: NCT06778122.
Disclaimer
This material on this page is ©2025 American Society of Clinical Oncology, all rights reserved. Licensing available upon request. For more information, please contact licensing@asco.org
Author Details
Eva Hernandez-Garcia
The Bartlett School of Sustainable Construction, University College London (UCL), London, United Kingdom
Authors chevron_right
Associated Organizations chevron_right
Abstract Details
Meeting
2025 ASCO Annual Meeting
Session Type
Poster Session
Session Title
Symptom Science and Palliative Care
Track
Symptom Science and Palliative Care
View MoreAbstract Disclosure
open_in_new
Similar Abstracts
text_snippet
Abstract
2023 ASCO Annual Meeting
First Author: Po-Ju Lin
text_snippet
Abstract
2023 ASCO Annual Meeting
First Author: Charles Stewart Kamen
text_snippet
Abstract
2023 ASCO Annual Meeting
First Author: Vidhya Nair
text_snippet
Abstract
2024 ASCO Gastrointestinal Cancers Symposium
First Author: Reema Anil Patel
Download
Your Privacy
ASCO is committed to transparency regarding our websites and the ways we process data. When you visit our site, we may store or retrieve information on your browser, mostly in the form of cookies. This information might be about you, your preferences, your location, or your device and is mostly used to make the site work as you expect it to and to personalize your web experience with us.
Because we respect your right to privacy, you can choose not to allow some or all types of cookies. Click on the different category headings to find out more about the types of cookies used on our websites and change your default settings to match your preferences. Please read these carefully. Blocking some types of cookies may impact your experience on the site, including our ability to personalize the content you receive from us.
For a full explanation of the personal and non-personal information we collect on our site, including how we use that information and your rights regarding that information, please review our Privacy Policy. Use of our website is also subject to our Terms of Use.
Allow All
Manage Consent Preferences
Essential Website Cookies
Always Active
These cookies are necessary for the website to function and are sometimes referred to as “strictly necessary” cookies. They make sure the website delivers you information and services in an optimal way.
They are often set in response to an action you take, such as changing your cookie preferences, setting your privacy preferences, logging in to our website, asking the site to remember you on subsequent pages, or filling in forms. These cookies do not identify you personally.
You can set your browser to block or alert you about all cookies, including essential website cookies, but some parts of the site will not work as a result.
Cookies Details‎
Performance and Functionality Cookies
Performance and Functionality Cookies
These cookies enhance the performance and functionality of our websites and the services we provide. For example, these cookies can keep track of your visitor session in between visits, enable you to share content through social media, use embedded media players, and use comment features. They also help us balance website load and improve site speed and performance.
All information these cookies collect is aggregated and therefore anonymous. These cookies may be set by us or by third party providers whose services we have added to our websites. These cookies are non-essential, but without these cookies, certain functionality or enhanced features may become unavailable.
Cookies Details‎
Personalization and Analytics Cookies
Personalization and Analytics Cookies
These cookies collect information that is used to help us understand how our websites and content are used, help us customize our websites and application for you in order to enhance your experience, and help us improve the content that ASCO creates to better meet our members’ and visitors’ needs. Examples include cookies that show us which content might be most popular with our visitors, understand browsing history of our users, understand the effectiveness of our own advertising, and enable us to recommend content to individual users based on their profile and activities on the website.
These cookies may be set by us or by third party providers whose services we have added to our websites.
These cookies are non-essential to the functionality of the site and may contain information that enables us or our third party providers to identify you and build a profile of your interests. Without these cookies, you will not be able to have a customized or personalized experience within our website.
Cookies Details‎
Advertising Cookies and Social Media Cookies
Advertising Cookies and Social Media Cookies
Advertising (or Targeting) cookies are third party cookies that may be set through our site by our advertising partners. They may be used by those companies to build a profile of your interests and show you relevant ads on other sites.
Social Media Cookies are cookies set by a range of social media services that we have added to the site to enable you to share our content with your friends and networks. They are capable of tracking your activities across other sites and building a profile of your interests. This may impact the content and messages you see on other websites you visit.
These cookies and the data collected by the third parties may be combined with data from other users or data about your activity on other sites. While the data collected on our site is aggregate or non-personal, the data may be used by such third parties to link you on other platforms or otherwise identify you.
If you do not allow these cookies, you may experience less targeted advertising.
Cookies Details‎
Back Button
Cookie List
Search Icon
Filter Icon
Clear
checkbox labellabel
ApplyCancel
ConsentLeg.Interest
checkbox labellabel
checkbox labellabel
checkbox labellabel
View Cookies
Name
cookie name
Save Settings
